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Causes and Risk Factors Centrilobular emphysema develops primarily from cigarette smoking, though genetic predisposition and environmental exposures also contribute to disease risk and progression

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AAS can cause significant alterations in the density of serotoninergic receptors in animals, leading to an established anabolic steroid-serotonin connection, which is believed to be the underpinning of why there is a change in emotional state and behavior with steroid use [R]