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The neurobiological phenotype of SZ involves dysfunction of similar neurotransmitters, such as the dopaminergic, glutamatergic and GABAergic systems, as well as overarching dysfunction of cortical and subcortical communicative circuitry

Reduced absorption may necessitate higher doses, increasing the risk of adverse effects, while reduced mucociliary clearance may put patients at greater risk of acquiring respiratory infections or pneumonia

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Pros Larger capacity for cannabis Slow, flavorful burn Popular in social settings Cons Contains tobacco Can be harsh for new users Joints or Prerolls Joints or prerolls are the classic cannabis roll, made with thin rolling papers and filled only with cannabis

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