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Other factors that interfere with normal eustachian tube functions include: Inflammation caused by pollutants and smoke in your respiratory tract leads to an excessive discharge of mucus that blocks ear drainage, causing infection

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Hybrid secretory/early ciliating cells preferentially lose ciliogenic function, potentially hindering regeneration of ciliated cells upon injury, and tuft-like cells are pushed toward functionally impaired ionocyte- or PNEC-like states