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Study outcome measures Primary endpoint Nicotine PK assessment On each study day (Days 18), before, during and after product use, blood samples were collected either by direct venepuncture or from a cannula placed in a forearm vein, at the following times: 5 min before product use ( 5 min), and then at 1, 3, 5, 7, 9, 15, 30, 45, 60, 90 and 120 min

Rechargeable, refillable and replaceable pod systems remain legal for adult purchase

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The spray may cause coughing, runny nose or watery eyes during the first week or two