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Brain 141, 688697

Accumulation of mtDNA damage could impair the OXPHOS system, leading to defects in electron transport chain (ETC) activity, increased ROS generation, and progressive bioenergetic failure, which contribute to the pathogenesis and progression of NDDs [10]

Supplements are not intended as a substitute for a varied and balanced diet and a healthy lifestyle

These include synthetic pharmaceuticals such as metformin, phenformin or phenobarbital, as well as naturally occurring substances such as resveratrol, berberine [128], and, discussed in this article, CGA [129]

Phytotherap Res 29(6):796804 Sulastri E, Zubair MS, Anas NI, Abidin S, Hardani R, Yulianti R (2018) Total phenolic total flavonoid quercetin content and antioxidant activity of standardized extract of Moringa oleifera leaf from regions with different elevation

Furthermore, various mitochondrial genes and metabolism both play an important role in this process (Dixon et al., 2017)