does semaglutide stop working after a year Woman shares journey of weight loss and gain using Weight Loss Plateaus on Semaglutide:

Others may use it for a shorter time to help with weight loss

HPG Axis Signalling and Spermatogenesis Research Luteinizing hormone-driven testosterone is central to spermatogenesis, with LH acting on Leydig cells to stimulate steroid production and intratesticular testosterone binding to androgen receptors on Sertoli cells influencing gene transcription and paracrine signalling required for germ cell development

Oral presentation: presentation number 54)

Real-time reverse transcription-polymerase chain reaction (RT-qPCR) Dissected tissues were subjected to total RNA extraction using TRI reagent (Molecular Research Center, Cincinnati, OH, USA) according to the manufacturers instructions

Diet None, just more protein

If these dont work, your doctor may be able to recommend other treatment options