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10 The primary role of GLP-1s is glucose and weight regulation, but the cardiovascular findings point to a broader impact on long-term health

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Fetal risks include the fetus developing hyperthyroidism or hypothyroidism (thyroid antibodies may cross the placental barrier)

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Our study confirms more recent findings that opioid receptors are up-regulated in tissue in response to pain, particularly pain associated with inflammation. Ogru said a topical opioid product could eliminate the side effects associated with oral delivery and could be suitable for a number of hard-to-treat pain types such as diabetic neuropathy

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