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A Cleveland Clinic review notes that one case report described symptoms only after a cumulative 15,000 mcg (15 mg) of injected B12 over several weeks

Though considered rare, some people have reported anaphylactic responses

However, high-quality research needs to be done to determine the impact of vitamin B12 itself on weight loss

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For this reason, bacteriostatic water-diluted medications should be used during pregnancy only if clearly needed and if the potential benefit justifies any potential risk to the fetus

Wrinkle improvement is gradual and cumulative