Of 18 SLE patients on GLP-1 medications, only one experienced a mild-to-moderate flare during follow-up
While nausea, vomiting, and diarrhea are the most commonly reported gastrointestinal adverse effects with GLP-1-based therapies (occurring in 15-40% of patients depending on the agent and dose), FDA prescribing information for several of these medications does list dyspepsia (indigestion) and, in some cases, gastroesophageal reflux disease (GERD) as reported adverse reactions
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Oxidative stress is a recognized contributor to heart failure progression [29], [30], and previous studies have pointed out changes in the redox status of glutathione in the failing heart
They tend to reduce alcohol and stress with things like short daily breathwork or counseling
Increase to 1mg daily and extend the evaluation window to 16 weeks