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Concentration matrices, temporal exposure strategies, mechanistic readouts, scaffold design, and long-term remodeling assessments are essential to move from speculative appeal toward validated research relevance

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The Continuum Concept, one of the most fundamental principles of physiology, biology, and disease, explains the status of an individual from optimal health to a hidden imbalance, progressing to severe dysfunction, ultimately leading to disease (41)

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Dosing tends toward the higher end of the standard range, often 0.5 mg daily throughout the treatment period

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