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[DOI] [PubMed] [Google Scholar] 148

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Human alveolar macrophages: comparison of cell size, autofluorescence, and HLA-DR antigen expression in smokers and nonsmokers

Increased tolerance, withdrawal symptoms upon cessation, a fixation on obtaining and using the drug, forsaking key responsibilities, alterations in sleep patterns, mood instability, secretive behavior, and engaging in dangerous activities are indicative of this addiction