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Traditionally, studies on the pathogenesis of COPD have often used CS exposure in vivo and in vitro

This was done either by inhalation or by injecting them with a solution bubbled with smoke

One possible explanation for these regions of relative deactivation may be the shift from ventral to dorsal striatum that occurs as drug use becomes habitual and compulsive 29 , and the finding that dysfunctional inhibitory mechanisms in the prefrontal cortex also play a role in addictive behaviour 29, 30

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Research on stress and smoking: progress and problems