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Administration of a pharmacological dose of recombinant human ghrelin increased proximal gastric tone through central and peripheral effects ( A synthetic pentapeptide ghrelin receptor agonist, relamorelin, is 15130 times more potent than natural ghrelin (Figure 1 in patients with either type 1 or type 2 diabetes mellitus with prior documentation of delayed gastric emptying (Figure 2 ( FIGURE 1 FIGURE 2 Motilin Receptor Agonists The most common motilin receptor agonists are the macrolide antibiotics that stimulate gastrointestinal motilin receptors, especially gastric receptors

Beginners should start at 250 mcg daily to assess individual tolerance and response before potentially increasing the dose

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