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This dual action activates regenerative TGF- signaling while blocking fibrotic TGF-1/Smad2/3 pathways, demonstrating context-dependent regulatory sophistication

The blend is used in tendon, ligament, and musculoskeletal injury models

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Therefore, since the NRF-2 protein is not exposed to KEAP1, it can adopt a translocation to the nucleus and join genetic regions that have detoxifying enzymes as an end product (e.g., NADPH, glutathione peroxidase, ferritin, and heme oxygenase-1) or antioxidant proteins [16,2224]

Materia i metody: Autorzy przegldu niezalenie przeszukali i ocenili badania dostpne w medycznych bazach danych takich jak PubMed, Scopus oraz repozytoria instytucjonalne

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