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Suppressing microtubule detyrosination reduces the stiffness of failing cardiomyocytes and improves relaxation kinetics, suggesting potential for microtubule-targeted interventions in the treatment of patients with HFpEF[163]

The number of participants on SGLT2is was low and the study duration was likely not long enough to demonstrate synergy between the 2 therapies

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Antipsychotics (e.g., chlorpromazine, haloperidol derivatives) alter membrane structure or inhibit calmodulin, potentiating antifungal agents (Stylianou et al., 2014

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