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Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease

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It provides cysteine, the rate-limiting substrate for endogenous glutathione synthesis, and consistently raises intracellular GSH in clinical trials

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Brain GSH levels are significantly reduced following TBI induced by controlled cortical impact in rats (Tyurin et al., 2000)

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