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This translated into a significantly higher likelihood of achieving the conventional glycemic target of HbA1c 30, those randomized to tirzepatide experienced 36 adjudicated cardiovascular deaths or heart failure worsening events versus 56 in the placebo group, representing a 38% reduction primarily driven by fewer heart failure exacerbations

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Regarding pancreatic -cells, it makes sense to monitor graft survival in patients with pancreatic -cell transplantation with GLP-1R molecular imaging

Drug-Drug Interactions: No interactions found/established

The SURMOUNT-1 trial demonstrated that participants on 15 mg tirzepatide lost an average of 20.9% of their body weight over 72 weeks

In addition to its metabolic effects, prolactin has been shown to modulate the immune system, particularly in the context of chronic hepatitis C