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[DOI] [PubMed] [Google Scholar] 97.Meijnikman A S, Nieuwdorp M, Schnabl B

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The threshold for significance was set at an adjusted P 1 and adjusted P 0.05)

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This is not surprising since NAC is only effective when cellular glutathione has been acutely (rather than chronically) depleted such as during acetaminophen (paracetamol) overdose

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Indeed, murine sepsis models further demonstrate that GR deletions in hepatic or endothelial cell lineages exacerbate inflammation and reduce survival (322, 325), underscoring the importance of tissue GR function in sepsis

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