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Both medications reduce acid production and slow gastric emptying

Unlike most GLP-1R agonist research compounds which are based on the GLP-1 peptide sequence, Tirzepatide uses a modified GIP sequence as its structural backbone while incorporating modifications that confer GLP-1R activity

Semaglutide users often experience reduced thirst perception and may drink less water than before treatment

PMID: 2 Institute of Medicine