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O-GlcNAcylation of ZEB1 facilitated mesenchymal pancreatic cancer cell ferroptosis

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Eating small but frequent meals is advisable to prevent glucose spikes

For some patients, side effects last longer and require provider-guided changes

PMID: 28805671

Ferroptosis does not require a specific pro-death signaling pathway but is triggered spontaneously when the protection of cellular membrane phospholipids from peroxidation by the metabolites and enzymes, including cysteine and glutathione peroxidase 4 (GPX4), are weakened [228, 229]