Regular blood tests are essential to keep levels within the therapeutic range and to avoid side effects such as kidney damage or infections
Structured programs providing regular contact with healthcare professionals, self-monitoring tools, and behavioral strategies show superior outcomes compared to general advice alone
placebo preserved 5.5% additional weight loss at 88 weeks Typical taper window / 8 to 16 weeks of stepwise dose reduction before full stop Switching GLP-1s / direct substitution on the same injection day is generally well tolerated per clinical practice guidelines Long-term therapy indication / AACE guidelines classify obesity as a chronic disease requiring ongoing treatment Cardiovascular benefit / SELECT trial showed 20% MACE reduction with semaglutide 2.4 mg over 34.2 months Why stopping a GLP-1 abruptly almost always triggers weight regain Abrupt discontinuation of a GLP-1 receptor agonist removes a pharmacological brake on appetite, gastric emptying, and reward-pathway signaling all at once
JAMA Dermatol 157(8):940946 Haran K et al (2024) Impact of GLP-1 receptor agonists on psoriasis and cardiovascular comorbidities: a narrative review
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29 , 40 Asimismo, los iSGLT2 tambin producen aumento del glucagn, gluconeognesis heptica 29 , 41 y riesgo de cetoacidosis euglucmica, efectos que podran contrarrestarse con los AGLP1, dando soporte fisiolgico a su combinacin