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The references below cite published preclinical research conducted in animal models and in vitro systems

For example: Certain antibiotics (such as chloramphenicol) may reduce the effectiveness of B12 therapy

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Patients with very low body fat may use a 5/16-inch needle

(1994, USA) had 13 students change from a lacto-ovo vegetarian to a vegan diet: All 4 with sB12 in the 600-900 range fell to below 500 pg/ml in 2 months

Gently aspirate by pulling back slightly on the plunger to check for blood: If blood appears , stop, withdraw, and restart in a new spot