While this explanation touches on some interesting concepts, there are several points that need clarification and might be oversimplified or speculative: Lets start with neuronal compensation
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Unlike oral B12 tablets, B12 injections are rapidly absorbed by the body immediately after administration and do not pass through the digestive system
Minimal response may warrant increasing by 50-100mcg
Signalling-molecule effects: 1-methylnicotinamide is itself a signalling molecule
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