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While GHSR1a activity in the hypothalamus is likely heavily involved in homeostatic mechanisms, its presence in extra hypothalamic regions, including a number of limbic and midbrain structures like the ventral tegmental area (VTA), suggest that this receptor is associated in processes associated with learning and motivation (Abizaid et al., 2006

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It is also at the center of 2026's regulatory shift in April the FDA removed it from the list that restricted compounding, and it is one of seven peptides under formal advisory review on July 2324, 2026

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