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Garcia-Echeverria et al (2004) presented a new compound (a pyrrolo[2,3-d] pyrimidine) that although inhibiting the IGF-1R and IR TK equipotently in cell-free systems, exhibited several-fold selectivity for the IGF-1R in a cellular context and reduced the growth of IGF-1R positive fibrosarcomas in vivo

The main concern is early worsening of existing diabetic retinopathy when glucose improves quickly, which can lead to permanent damage if untreated

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At ~4000 m, HACE affects approximately 0.281% of people, including trekkers, sojourners, workers, climbers, and soldiers